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Exogenous GH injections bypass the hypothalamicpituitary control loop, often creating supraphysiologic peaks and sustained IGF-1 elevation
However, high doses (a single intraperitoneal injection of 250 mg/kg) of FA can also cause AKI in mice, and continuous injection can cause AKI to convert to chronic kidney disease (CKD) in mice 347
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However, high supplemental doses of niacin may cause niacin flush, nausea, vomiting, stomach irritation and liver damage
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